Antimicrobial effects of syndiotactic polypeptides

Helical antimicrobial polypeptides with radial amphiphilicity.

α-Helical antimicrobial peptides (AMPs) generally have facially amphiphilic structures that may lead to undesired peptide interactions with blood proteins and self-aggregation due to exposed hydrophobic surfaces. Here we report the design of a class of cationic, helical homo-polypeptide antimicrobials with a hydrophobic internal helical core and a charged exterior shell, possessing unprecedente...

Properties and Structures of Sulfonated Syndiotactic Polystyrene Aerogel and Syndiotactic Polystyrene/silica Hybrid Aerogel

Antimicrobial polypeptides in host defense of the respiratory tract

The large surfaces of the respiratory tract are often the initial site of contact between microbes and their human hosts. Respiratory epithelia are coated with a thin layer of airway and alveolar secretions whose composition varies by anatomical location and in response to mechanical, chemical, and microbial stimulation. In the nose, trachea, and bronchi, the secretions are generated by airway ...

Antimicrobial polypeptides in host defense of the respiratory tract.

The large surfaces of the respiratory tract are often the initial site of contact between microbes and their human hosts. Respiratory epithelia are coated with a thin layer of airway and alveolar secretions whose composition varies by anatomical location and in response to mechanical, chemical, and microbial stimulation. In the nose, trachea, and bronchi, the secretions are generated by airway ...

Synthesis and Development of Some Biodegradable Polypeptides as Antimicrobial Agents

Biodegradable and bioactive polymers are gaining considerable attention in the field of biomedical research to achieve therapeutic effects, drug-targeting and as drug carriers. Two acidic amino acid (glutamic and aspartic acids) monomer units were converted into polyanionic long chain polypeptidespoly-glutamic acid (PGA) and poly-aspartic acids (PAA). The synthesized derivatives were characteri...